Effect of proteinous compounds from Portulaca oleracea L. plant on some biochemical parameters in mice

169 Abstract Two proteinous compounds (A and B) were isolated by gel filtration chromatography of the acetone precipitate of the aqueous extract of Portulaca oleracea L. plant. Comparative apparent molecular weights determination by gel filtration using standard proteins gave a value of 28184 and 2291 dalton respectively.The effect of the isolated proteinous compounds A , B and the hormone of insulin on some biochemical parameters such as blood glucose , cholesterol , triglycerides ,total lipids levels and glycogen content in liver tissues was studied in fasting mice. A single intraperitoneal injection of the isolated compounds (A ,B) at a dose of 77.5 mg/kg B.W. was given to normal mice which showed a significant decrease of serum glucose, cholesterol, triglycerides, total lipids level and glycogen content in liver tissues when compared to the controlled group, wherease insulin and compound B showed a significant increase in glycogen content of liver tissues.